To build a net zero economy, the world needs to build a net zero chemicals industry. Chemicals are present in over 90% of manufactured goods, and account for a large portion of global emissions. But in order for this large and high-emitting sector to transition, it needs clear guidance, frameworks, and standards to facilitate its transition to net zero. There is a small window of opportunity to equip the European chemicals sector with the green technologies necessary to reach net zero by 2050, and without clear policy guidance and support, the industry won’t be able to reach its goals. This policy brief aims to guide the EU chemicals sector toward a rapid, robust, and credible transition to net zero.